421 W. 2nd St. is a 0.20 acre commercial lot with an existing 2,736 ± SF building, located just west of downtown Defiance. Positioned along W. 2nd St., the site offers strong local visibility and convenient access for a range of business types. The property is surrounded by a mix of residential neighborhoods and established commercial users. Nearby retailers and services include CVS, Family Dollar, Sherwin-Williams, Rite Aid, Kroger, and various restaurants, auto shops, and gas stations. Traffic along W. 2nd St. benefits from consistent daily volumes, with additional flow driven by nearby Clinton St. (OH-66), one of Defiance’s primary commercial corridors. The location is approximately 1.5 miles from U.S. Route 24, providing quick expressway access to Toledo, Fort Wayne, and surrounding markets. State Route 15 is also close by, enhancing regional connectivity. Zoned for commercial use by the City of Defiance, the property is suitable for retail, service, office, or redevelopment opportunities.